In order to verify the applicability of rainfall data of TRMM (Tropical Rainfall Measurement Mission) in karst area, this study takes Guizhou Province as the research area and uses the precipitation record of 19 meteorological stations in Guizhou Province from 1998 to 2015, and on the yearly and monthly scale the accuracy of precipitation data of TRMM satellite is verified, and the temporal and spatial distribution characteristics of precipitation in Guizhou Province are analyzed based on the monthly precipitation data of TRMM . The results show that the TRMM precipitation data can reflect the spatial distribution and evolution of precipitation. On the yearly scale, the correlation coefficient between the TRMM precipitation data and the observed data from metrological stations is R=0.817 and, the slope is K=0.751. The data accuracy is high, and the TRMM precipitation data value is slightly higher than the observed data form metrological stations. On the monthly scale, the correlation coefficient between TRMM precipitation data and site precipitation is 0.927, which is the highest,and the slope is 0.9127.The value of former is slightly higher than that of the measured precipitation. In areas with an altitude greater than 1 300 m and a slope less than 10°, TRMM precipitation data is more accurate. The analysis shows that the effect of elevation on the accuracy of TRMM precipitation data is greater than that of slope and aspect. In general, the TRMM precipitation data has a certain accuracy in the karst area, but the accuracy in the area with less precipitation or complex terrain is relatively low.