Hydrological model plays an important role in hydrological theory research and practice. Taking the above area of Xishan hydrological station in Qujiang River basin as a study area, the applicability of the Xin'Anjiang model in this area was analyzed. The results show that Xin'anjiang model performs well in the simulation in Qujiang River basin, with Nash coefficient above 0.7 and the error of water balance controlled within ±10% for most catchments. The length of data sequence has significant influence on simulation effect. The simulation results in the stations with longer length of data sequence like Eshan and Xishanare are much better than in Dayizi and Majiazhuang stations. The Xin'anjiang model is suitable for the mountainous areas of southern China, and has good applicability to the study of the hydrological process in the changing environment.