Optimal operation of cascade pumping station group is a nonlinear, multi-stage, and multi-dimensional complex scientific problem. In order to solve the problem of low operation efficiency and high energy consumption of cascade pumping station, the study on daily optimizing operation of the blade-adjusting of cascade pumping station is carried out. The dynamic programming successive approximation was used to conduct optimized calculation on the blade-adjusting operation of multi-set of single-stage pump station, then the reverse look-up table method was adopted to solve daily optimal operation problem of cascade pumping stations, at last, the study on the south-north water transfer into cascade pumping station project of Miyun reservoir was conducted. Considering the influence of the peak and valley electricity price, the total daily water withdrawal of cascade pumping stations is 176.36×104 m3, the efficiency of pumping station is 43.27%, the operation cost of cascade pumping stations is reduced by 23.77% after optimization, and the optimization effect is obvious.