Polyurea anti-seepage materials are widely used in large water conservancy and hydropower project. Under the condition of seepage control in the project，it is of great practical significance to select rational laying thickness and laying method for saving project investment. A contact model is established between concrete blocks and polyuria anti-seepage materials, and Ogden material is used to simulate the polyurea anti-seepage materials, and ADINA commercial software is used to analyze the influence that the coating thickness and cushion layer width make on the Polyurea stress and the deformation characteristics. The research result shows that the maximum stress and the maximum thickness changes of anti-seepage materials are related to the opening degree, water depth, coating layer thickness, and cushion layer width, and cushion layer width has a great influence on the maximum stress and the maximum thickness changes.