The tide and wind provide huge energy for the movements of the estuary nutrients and sediments. In this study, a three-dimensional numerical model of the Pearl River Estuary was established to evaluate the effects of wind on the tidal energy flux and dissipation in the Huangmaohai Estuary. The results showed that the tidal wave can propagate along the deep trough to the estuary and delta, the effects of wind changed the amplitude and phase of the energy flux in the estuary, and it had little effect on the average energy flux of each section. The total energy consumption increased 0.16~0.8 times than that without wind effect. The vertical eddy kinetic energy was 35% ~ 53% of the total energy consumption, it increased by about 0.5~1.7 times. The friction energy consumption was 46% ~ 64% of the total energy consumption which decreased about 5%. The effects of strong wind would increase unit energy consumption, vertical eddy dynamic energy consumption, reduce friction energy loss, but did not change the spatial distribution pattern of the energy dissipation produced by morphological resistance.