The resistance loss is one of the key parameters of pipeline transportation.Based on the pipeline flushing test at Xiaolangdi Reservoir, this article studied the resistance loss of pipeline transportation in different flow rates, particle sizes and concentrations.It took the method of measured data with model and chose the model which has the best fitting effect.During the test, when the flow speed is 2.08m/s, the fitting effect of resistance model with Fei Xiangjun model is the best, Durand model is the second.So the paper comprehensively considered the models of both Fei Xiangjun and Du Lande in the determination of parameter. In this experiment, the discharge is 620 m3/h (flow rate is 2.08m/s), the sediment concentration is 279 kg/m3 (concentration 10.53%), and the median particle size is 0.0512mm, the sand flushing effect is better,the monthly sediment discharge is 41500 t. Based on condition of this test, the paper predicted the sand flushing effect of higher sediment concentration.The optimal parameters are that the discharge is 620 m3/h (flow rate is 2.08m/s), the sediment concentration is 950 kg/m3 (concentration 35.85%), and the median particle size is 0.0512mm, the monthly sediment discharge is141400 t.