Based on the data of water resources, social and economy of 13 cities of Jiangsu province from 2009 to 2013,the paper used the method of data envelopment analysis to calculate the water use efficiency of 13 cities in different periods by taking the water use of every sector, gross fixed asset investment, employed population as the input index, GDP, COD, ammonia nitrogen emissions as the output index.It analyzed the spatial and temporal disparities and spatial correlation by method of exploratory spatial data analysis and finally analyzed the influence factors of water use efficiency in Jiangsu province by spatial Durbin model. The results showed the water use efficiency of Jiangsu province is high.There is obvious regional difference in space; there is a positive spatial correlation between water use efficiencies every region The science development index, the ratio of foreign investment, the ratio of the tertiary added value and the investment of pollution management have positive impact on water use efficiency.The water per person, the ratio of agriculture water use have passive impact on water use efficiency.