The effect of chemical corrosion and high temperature on the physical and mechanical properties of Ningde white sandstone in Fujian Province was investigated. The specimens were firstly immersed into HNO3 solution and kept for 90 days, and then were heated up to different temperatures ranging at 200,400,600 and 800℃. The paper examined physical parameter and mechanical properties under uni- and tri-axial compression and analyzed the influence of chemical corrosion and high temperature on stress-strain curve, peak stress and elastic modulus.Results show that the effect of chemical corrosion and high temperature on the physical and mechanical properties of white sandstone is not the same.Tthe HNO3 immersion and heating deteriorated the internal structure of white stone specimens, increased porosity and resulted in the decrease of elasticity modulus.On the other hand, the shape of the stress-strain curves in four stages also changes due to the chemical corrosion and thermal effect, and the peak stress loss increases as the temperature increases. Furthermore, the confining pressure in tri-axial compression is beneficial to the mechanical properties of white sandstone compared to uni-axial compression. For uni-axial compression, both the physical and mechanical properties are deteriorated due to the chemical corrosion and high temperature in the way that the peak stress loss is in a linear relationship with elastic modulus loss. For tri-axial compression,only when the loss rate of elastic modulus is larger than 14%,the peak stress of white sandstone is damaged.Otherwise the peak stress increases instead of decreasing.