In view of features of seriously pollution and highly managing cost for multicomponent contaminated groundwater, by means of the waste tire rubber after crushing the preparation of colloidal particles as the active material of PRB system for adaptability of conditions research on adsorption effect of COD, NH+4—N, Fe2+, Mn2+, SO42- in contaminated groundwater .The results showed that under the conditions of the colloidal dosage 0.5 g/200mL, the oscillation frequency 150 r/min, reaction time 36 h, pH 7, COD, NH+4—N, Fe2+, Mn2+, SO42- removal rates in contaminated groundwater were 44.3%, 24.8%, 96.2%, 86.2%, 9.5%,which showed that the particles has better removal effect on COD, Fe2+, Mn2+ pollution.The particles of COD (sodium lactate) adsorption characteristics can be better with the Temkin adsorption isotherm model and dynamic model of Elovich.This method has a certain positive significance to broaden the utilization of waste rubber resources and to repair the underground water containing organic matter and iron and manganese pollution.