The paper selected Wavelet and GIS analysis to research the law of temporal and spatial variation of runoff and analyzed the runoff series in controled hydrology station of Kuye river from 1956 to 2009.Results shows that Morlet wavelet can better characterize the time-frequency localization characteristics of average annual runoffl and more accurately analyze the periodic and singularity of runoff time series;by use of powerful spatial interpolation function of GIS ,it visually analyzed the spatial distribution regularity of runoff in Ku-ye river basin in different time scales.This method can provide a scientific reference for the development of similar study.