Taking different supports (zeolite，ceramsite and silica gel）as carrier，the paper prepared different nickel-based catalysts such as Ni/zeolite，Ni/ceramsite and Ni/silica gel through impregnation.The three kinds of catalysts were characterized by means of scanning electron microscope (SEM)，X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)，and investigated the different nickel-based catalysts catalyzing sodium persulfate (PS) for the experiments of degrading the acid orange 7(AO7).The results showed that the main load of different nickel-based catalysts is NiO.The degradation rate of AO7 can achieve 33.1%，44.7% and 44.7% respectively with catalysts of Ni/zeolite，Ni/ceramsite and Ni/silica gel. Compared with Ni/zeolite and Ni/ceramsite，the main reason for Ni/silica gel having good activity probably derived from the good crystallinity，the largest dispersity，the smallest size of Nickel grain and the more active of the interaction with nickel active component.