The Ma'anshan section of the Yangtze River is the most important water source of Ma'anshan and the section still collect city's industrial wastewater and domestic sewage.Therefore, it is more important to establish the evaluation and prediction model of water quality which can predict the effect of pollution discharge on water quality in Ma'anshan section of the river.The influence scope and extent of pollution discharge on water quality could be forecasted through establishing the two dimensional simulation and prediction model of inland waters in Ma'anshan section of the Yangtze River. The concentration distribution of pollutants NH3-N, TP and F- in this section were investigated. The results showed that the influence of pollution discharge on Guxi river is obvious, but the mixing zone width of pollutants is less than 100m.The pollution band has the impact scope of a thousand meters on overall water quality in downstream of the river. The water quality can basically reach the requirements of class II in Ma'anshan section of the Yangtze River. At the same time, the prediction model of two-dimensional simulation has certain guiding significance for the measure of pollution control,forecast of major emergencies and adjustment of industry structure and layout along the Yangtze Rive.