In order to meet the needs of development, utilization, protection, and water administration of water resources in Wuxi,the paper reasonably analyzed the water function zone from the layout water source area, social and economic development,the install of sewage discharge control zone and transition zone norms based on the existing water function zoning of Wuxi. It used the mathematical model of water environment in Wuxi which was established before to calculate the lengths of sewage discharge control zone and transition zone.Finally,it proposed an adjustment scheme of water function zones of Wuxi. The scheme includes that to increase four drinking water source protection zones and adjust scope of one water functional zone according to the water source area layout; to increase four industrial, agricultural, recreational water zones according to the social and economic development layout, wherein the two zones comes from other functional zones;to increase ten transition zones according to the requiremenr of transition zone;to increase thirteen sewage discharge control zones according to transition zone setting norms.The results can provide new idea for management of water function zone in Wuxi.