The dringking of groundwater with high level of fluorine can lead to provincial fluorosis.This paper used the correlation analysis in multivariate statistical methods to evaluation the groundwater quality inYuncheng basin, and then studied the correlation and variation characteristics between fluorine in groundwater with high level of fluorine and other water chemical indicators in Yuncheng basin. Analysis results show that there is markedly positive correlation relationship between fluorine content in groundwater and the water chemical indicators of pH、SO42-、Cl-、HCO-3 and temperature, and there is negative correlation between fluorine and Ca2+. The alkaline environment and high salinity are beneficial for the formation of high fluorine water, and high calcium ion concentration can restrain the increase of fluorine concentration. The concentration of fluorine, chlorine ion and sulfate in groundwater showes the trend gradual increase, which indicates the associated relationship between the increase of fluorine concentration and salt accumulation process.