Taking four endocrine-disrupting compounds (EDCs) as target substance,the paper researched the distribution and removal rate of EDCs in process of a sewage treatment plant (STP), and further investigated the mechanisms of EDCs removal. All the target compounds were detected in the influent and effluent sewages. The mean concentrations of E2, EE2, 4-n-NP and BPA in water inlet were 64.8, 171.5, 115.4, 920.7 ng/L and that in water outlet were 22.8, 49.9, 50.9, and 84.3 ng/L. The removal of target compounds from sewage is mainly attributed to the biological treatment stage in STP. The mechanism of removal is largely biodegradation, and the rate of biodegradation is related to kinds of EDCs and types of sludge.The sludge adsorption might have certain influence on the removal of EDCs.