With the health risk assessment of groundwater pollution having been paid more attention gradually; more and more concern has focused on the influence degree and the development trend of its risk, therefore using analytical solution to simulate, predict and assess the health risk of groundwater pollution has been gradually applied as well. This paper aims to study the sensitivity of analytical solution model when simulating health risks of pollutants and underlying more extensive application of this method. It selects four parameters from analytical solution model ,including permeability coefficient (K), longitudinal dispersity (αx), pollutants organic carbon distribution coefficient (Koc) and half-life (t1/2).In the cases of other parameters being constant , it changes the value of each parameter successively and calculates analytical solution , records the corresponding parameter value and simulation results, draws simulated prediction value and each change curve of analytical parameter , elaborates the respond degree of analytical solution to each parameter, thus provides basis for coping with uncertain factors.