At present, the water quality criteria of heavy metals, which is not differentiated in the regions with different criteria, is based on the total metal concentration and unified in China. It is very necessary to do some research on the national standard for heavy metals of the ground water in different regions of China. With respect to the economic, rational, efficient and environmental friendly controlling of the heavy metals emission, the Biotic Ligand Model (BLM) is a promising method for establishing the national standard in varied regions. In spite of some challenges in improving and perfecting the BLM, it is believed that BLM will play an important role in the process of setting up the water quality criteria of national standard for heavy metals.