Through the experiments and dynamic analysis showed the introduction of ligands improve, enhance the system''s removal efficiency of tannery wastewater treatment which based on the fly ash of Fenton-like system. Meanwhile, obtained the optimal reaction conditions by EDTA-fly ash/H2O2 system to degrade and simulate the tannery wastewater as follows:At room temperature, the reaction pH value is 10, the initial COD value is 110.8mg/L, the hydrogen peroxide concentrations is 200.4mg/L, the concentration of EDTA is 250mmol/L, the dosing quantity of fly ash is 10 g/L, under these conditions the removal rate of COD and coloring are all above 95%. After useing of fly ash repeatly, the removal rate of COD has reached above 97%.