To address the water quality deterioration in plain river network areas, a case study of river scheduling schemes was carried out for the Xinjiangwei area of Kunshan High-Tech Zone. A hydrodynamic-water quality coupled model was first established, and an evaluation method for scheduling schemes based on a combined weighting cloud model was proposed. Various water transfer schemes were developed and then simulated by the coupled model to construct a water quality-quantity evaluation index system. The subjective weights of the indices were determined by the analytic hierarchy process (AHP), while the objective weights were obtained through the entropy weight and TOPSIS. The comprehensive weights of each index were then calculated by Nash equilibrium theory in game theory. Subsequently, the indices were classified into different grades, and the X-conditional cloud generator was employed to determine the membership degree of each grade. The comprehensive evaluation scores of all schemes were obtained by weighted summation of the comprehensive weights. The schemes were ranked in descending order as follows: scheme 5, scheme 7, scheme 3, scheme 4, scheme 6, scheme 2, scheme 1, and the initial scheduling scheme. According to the comparative analysis, scheme 5 was identified as the optimal comprehensive scheduling scheme. This scheme can ensure water quality improvement while minimizing the water transfer volume, providing a reference for research on water environment improvement through water transfer in plain river network regions.